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| Product Name | Tie2 Kinase Inhibitor |
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| Description | Purity >95%. Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues. Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM. It is 200-fold more potent for inhibition of Tie2 compared to p38. Tie2 kinase inhibitor has been shown to reduce angiogenesis in a neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine, Tunica Interna Endothelial Cell Kinase 2 Inhibitor |
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| Gene, Accession, CAS # | CAS: 948557-43-5 |
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| Catalog # | LS-H10221 |
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| Order / More Info | Tie2 Kinase Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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