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| Product Name | HIV-1 p24 core protein |
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| Description | HIV-1 p24 core protein.HIV-1 p24 Core is a non-glycosylated polypeptide chain,containing the full length sequence of the HIV-1 p24.Human immunodeficiency virus (HIV) is a retrovirusthatcan lead to a condition in which the immune systembeginsto fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helperT cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ Tcells through three main mechanisms: firstly, direct viralkilling of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ Tcells by CD8 cytotoxic lymphocytesthat recognize infectedcells. When CD4+ T cell numbers decline below a criticallevel, cell-mediated immunityis lost, and the body becomesprogressively more susceptible to opportunistic infections.HIV was classified as a member of the genus Lentivirus,part of the family of Retroviridae. Lentiviruses have manycommon morphologies and biological properties. Manyspecies are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a longincubation period. Lentiviruses are transmitted as singlestranded, positive-sense, enveloped RNA viruses. Uponentry of the target cell, the viral RNA genomeis convertedto double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNAis then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed.Once the virus has infected the cell, two pathways arepossible: either the virus becomes latentand the infectedcell continues to function, or the virus becomes active andreplicates, and a large number of virus particles are liberated that can then infect other cells. Purity >95% by SDS-PAGE and HPLC |
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| Size | 100 ug, 1 mg |
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| Concentration | n/a |
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| Applications | ELISA, WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | orb85303 |
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| Price | |
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| Order / More Info | HIV-1 p24 core protein from BIORBYT LTD. |
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| Product Specific References | n/a |
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