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| Antigenic Specificity | Myelin Basic Protein, aa82-91 |
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| Clone | 3H2751 |
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| Host Species | Mouse |
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| Reactive Species | cow |
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| Isotype | IgG2a |
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| Format | ascites |
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| Size | 250ul |
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| Concentration | n/a |
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| Applications | ELISA IHC WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | It appears to react with synthetic peptide 82-91 and human and bovine 45-91 but not with whole MBP molecules (Martensen numbering). This epitope is located in the C terminal region of 82-91 and the corresponding epitope is not present (or exposed) in whole MBP.The clone was selected using synthetic human MBP peptide 82-91 for screening (1). Since this work was done a seqence error has been described in the human MBP seqence in this region (3). Although the clone was selected to have a high affinity for 82-91 it appears that this antibody reacts more strongly with the unnatural sequence, rather than the correct human 82-91. In consequence the antibody is not a suitable reagent for sensitive immunoassays of correct human 82-91 as was thought at the time the original paper on this antibody was published (1).The 91-92 phe-phe bond is believed to be cleaved by demyelinating lesions by Cathepsin D to generate peptides ending in the phe 91 which should react with this monoclonal. |
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| Immunogen | Bovine Myelin Basic protein (MBP) (45-91) / Ovalbumin Conjugate. |
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| Other Names | Myelin Basic Protein, aa82-91 (MBP) |
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| Gene, Accession # | n/a |
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| Catalog # | M9758-03Q |
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| Price | |
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| Order / More Info | Myelin Basic Protein, aa82-91 Antibody from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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