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| Product Name | c-Met, Recombinant, Canine |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. HGF R, also known as Met (from N-methyl-N'-nitro-N-nitrosoguanidine induced), is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes posttranslational proteolytic cleavage. This generates a mature HGF R that is a disulfide-linked dimer composed of a 50 kD extracellular α chain and a 145 kD transmembrane β chain. 1,2 The extracellular domain (ECD) contains a seven bladed β- propeller sema domain, a cysteine-rich PSI/MRS region, and four Ig-like E-set domains, while the cytoplasmic region includes a tyrosine kinase domain. 3 The sema domain, which is formed by both the α and β chains of HGF R, mediates both ligand binding and receptor dimerization. 3,4 Ligand-induced tyrosine phosphorylation in the cytoplasmic region activates the kinase domain and provides dock |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | c-Met, Recombinant, Canine (Hepatocyte Growth Factor Receptor, Scatter Factor Receptor, HGFR, SFR) |
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| Gene, Accession, CAS # | SwissProt: Q75ZY9 |
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| Catalog # | M3007-13C |
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| Order / More Info | c-Met, Recombinant, Canine from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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