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| Product Name | c-Met Kinase, Control Peptide |
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| Description | Purified ~80% by HPLC, MS. MET, a high affinity receptor for hepatocyte growth factor (HGF; also known as scatter factor), is a disulfide-linked heterodimer made of 45kD a- and 145kD b-subunits (1,2). The a-subunit and the amino-terminal region of the b-subunit form the extracellular domain. The remainder of the b-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of MET with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase (3) and is critical for all of its known biological functions. Phosphorylation of Tyr1234/1235 in the MET kinase domain is critical to kinase activation. Phosphorylation of Tyr1349 in the MET cytoplasmic domain provides a direct binding site forGab1 (4). Altered MET levels and/or tyrosine kinase activities were found in different tumors, especially in renal, colon and breast cancers. Thus, MET is an attractive |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | c-Met Kinase, Control Peptide (Biotin) (Hepatocyte Growth Factor, Scatter Factor Receptor, HGF, SF) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M3007-07G |
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| Order / More Info | c-Met Kinase, Control Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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