| 产品详情 |
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| Product Name | c-Myc Inhibitor III, Mycro2 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50=23uM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPa homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50=>54uM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10uM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20uM). Formula: C17H11F3N4OS2 Primary Target: a-helical dimerization motifs of c-Myc/Max factors Primary Target IC50: IC50 = 23 and 54uM for c-Myc/Max and Max/Max dimerization Secondary target: a-helical dimerization motifs of Max/Max factors Molecular Weight: 408.4 Solubility: DMSO (100mg/ml clear, yellow solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | c-Myc Inhibitor III, Mycro2 (5-(Thiophen-2-yl)-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217235 |
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| Order / More Info | c-Myc Inhibitor III, Mycro2 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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