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| Product Name | C-myc, Recombinant, Human, His-Tag, Western Blot Positive Control |
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| Description | Highly Purified (~95%). Western Blot Positive Control for Myc gene was first discovered in Burkitt's lymphoma patients. In Burkitt's lymphoma, cancer cells show chromosomal translocations, in which Chromosome 8 is frequently involved. Cloning the break point of the fusion chromosomes revealed a gene that was similar to myelocytomatosis viral oncogene (v-Myc). The new cellular gene was named c-Myc. Human c-myc (accession # P01106; 439aa, chromosome 8q24) is a protooncogene, which is overexpressed in a wide range of human cancers. When it is specifically-mutated, or overexpressed, it increases cell proliferation and functions as an oncogene. It is a transcription factor that regulates expression of a great number of genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc belongs to Myc family of transcription factors, which also includes N-Myc and L- Myc genes. Myc-family transcription factors contain the bHLH/LZ (basic Helix-Loop-H |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P01106 |
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| Catalog # | 208765 |
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| Order / More Info | C-myc, Recombinant, Human, His-Tag, Western Blot Positive Control from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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