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| Product Name | CRIM1, Recombinant, Human (Cysteine-rich motor neuron 1 protein) |
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| Description | Purity ≥90% (SDS-PAGE). Cysteine rich motor neuron 1 (CRIM1) is a type I transmembrane glycoprotein of the chordin-like cysteine-rich repeat (CRR) family of BMP inhibitors. The ~130kD, 1036aa CRIM1 contains a 34aa signal sequence, a 905aa extracellular domain (ECD), a 21aa transmembrane domain and a 76aa cytoplasmic domain. The ECD includes an N-terminal IGF-binding protein-like motif and six chordin-like von Willebrand C-type CRRs. The ECD can be released from the cell , presumably by proteolytic processing. Human CRIM1 ECD shows 88%, 88%, 91%, 86%, 87%, 83% and 72% aa identity with mouse, rat , dog, cow, opossum, chick and zebrafish CRIM1 ECD, respectively. CRIM1 can interact with TGF-beta family ligands, including BMPs 2, 4 and 7, via its CRR domains. It binds BMPs intracellularly and antagonizes them by lowering their expression, processing and secretion. CRIM1 is expressed in the developing spinal cord in the floor plate and developing motor neurons. It is also expressed by periva |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9NZV1 |
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| Catalog # | C7935-66E |
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| Order / More Info | CRIM1, Recombinant, Human (Cysteine-rich motor neuron 1 protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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