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| Product Name | C8orf4, Recombinant, Human, aa1-106, GST-Tag (Uncharacterized Protein C8orf4) |
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| Description | Purity ~90% (SDS-PAGE). Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown. In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renew |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Thyroid cancer protein 1 |
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| Gene, Accession, CAS # | SwissProt: Q9NR00 |
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| Catalog # | 372526 |
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| Order / More Info | C8orf4, Recombinant, Human, aa1-106, GST-Tag (Uncharacterized Protein C8orf4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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