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| Product Name | AMIGO, Recombinant, Human, aa28-367 |
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| Description | Purity ~95% (SDS-PAGE). AMIGO (amphoterininduced gene and ORF) is an ~75kD transmembrane cell adhesion protein. It belongs to a family of leucinerich repeat (LRR) containing proteins that play various roles in nervous system development and function (1). Mature human AMIGO consists of a 345 amino acid (aa) extracellular domain (ECD) with six tandem LRRs flanked by LRR N and Cterminal domains, one immunoglobulinlike domain, a 21 aa transmembrane segment, and a 100 aa cytoplasmic domain (2). Within the ECD, human AMIGO shares 86% aa sequence identity with mouse and rat AMIGO. AMIGO is an Nglycosylated protein that forms homodimers by association between LRR regions (3, 4). It interacts homophilically as well as heterophilically with the related AMIGO2 and AMIGO3 proteins (2). AMIGO is expressed along developing and mature neuronal fiber tracts on neurons, astrocytes, and oligodendrocytes (2, 4). It promotes the extension and branching of hippocampal and cortical neurons (2, 4). It |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AMIGO, Recombinant, Human, aa28-367 (Alivin-2, AMIGO1, Amphoterin-induced Geneamphoterin-induced Gene and ORF, ORF) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145774 |
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| Order / More Info | AMIGO, Recombinant, Human, aa28-367 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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