| 产品详情 |
| Edit |   |
|---|
| Product Name | Delta-like Protein 1, Recombinant, Human |
|---|
| Description | Purity ≥ 90% (by SDS-PAGE under reducing conditions; visualized with silver staining and quantitative densitometry by Coomassie blue staining).Endotoxin: ≤ 0.10EU/ug protein (LAL method). Delta-like protein 1 (DLL1) is a 90-100kD type I transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature human DLL1 consists of a 528 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain (1). Within the ECD, human DLL1 shares 91% aa sequence identity with mouse and rat DLL1. It shares 26%, 37%, and 54% aa sequence identity with DLL2, 3, and 4, respectively. A 60kD ECD fragment released by ADAM9, 12, or 17 mediated proteolysis, promotes the proliferation of hematopoietic progenitor cells (2, 3). The residual membrane-bound portion of DLL1 can be cleaved by presenilin-dependent γ-secretase, enabling the cytoplasmic domain to migrate to the nucleus (4). |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Delta-like Protein 1, Recombinant, Human (DLL1, Delta-like 1, Delta1, DL1, H-Delta-1, UNQ146/PRO172) |
|---|
| Gene, Accession, CAS # | Accession: AAB61286 |
|---|
| Catalog # | D2727-73 |
|---|
| Price | |
|---|
| Order / More Info | Delta-like Protein 1, Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|