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| Product Name | L3MBTL1, Recombinant, Human, aa191-530, GST-tag (Lethal(3) Malignant Brain Tumor-Like Protein 1) |
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| Description | Purified (~88%). Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins, therey acting as a reader of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at Lys26 (H1bK26me1 and H1bK26me2) and histone H4 at Lys-20 (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at Lys-382, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at Lys-860. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. Source: Recombinant protein corresponding to aa191-530 from human L3MBTL1, fused to GST-tag at N-terminal, |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_015478, SwissProt: Q9Y468 |
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| Catalog # | 298421 |
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| Order / More Info | L3MBTL1, Recombinant, Human, aa191-530, GST-tag (Lethal(3) Malignant Brain Tumor-Like Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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