| 产品详情 |
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| Product Name | L3MBTL3 MBT Domain Blocker, UNC1215 |
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| Description | Purity ~98% (HPLC). A cell-permeable pyrrolidinyl-piperidinyl-benzamide that effectively competes against H4K20Me2 peptide for L3MBTL3 binding by targeting the first two L3MBTL3 MBT domains (Kd = 120nM in binding studies using recombinant 3MBT fragment), while exhibiting much reduced potency against L3MBTL1-H4K20Me1, 53BP1-H4K20Me2, MBTD1-H4K20Me1, or L3MBTL4-H2AK36Me1 interaction (IC50 ≥2uM; [peptide] = 150nM). Shown to increase GFP-L3MBTL fusion nucleus mobility (10nM to 1uM) in HEK293 transfectants. X-ray structural analysis reveals two 3MBT are bridged together by two UNC1215 molecules in a reciprocal fashion. Solubility: DMSO Primary Target: Kme binding ligand of L3MBTL3 Primary Target IC50: 40nM Primary Target Ki: 0.12u Molar Mass: 529.7 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | L3MBTL3 MBT Domain Blocker, UNC1215 (Lethal(3)malignant Brain Tumor-like Protein 3 MBT Domain Blocker, 2-Phenylamino-1,4-bis(4-(pyrrolidinyl)piperidinyl)benzamide, TFA, 2-(Phenylamino)-1,4-phenylene-bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, TFA) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217506 |
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| Order / More Info | L3MBTL3 MBT Domain Blocker, UNC1215 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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