| 产品详情 |
| Edit |   |
|---|
| Product Name | Chk2, active, Recombinant, Human (Checkpoint Kinase 2, Rad 53) |
|---|
| Description | Purity ≥ 90% by densitometry. Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner (1). Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Serine 20 and p53 stabilization (2). Source: Recombinant full-length human Chk2 was expressed by baculovirus in Sf 9 insect cells using an N-terminal GST tag. The gene accession number is NM_007194. Molecular Mass: The approximate molecular weight is 88kD. Activity: The specific activity of Chk2 was determined to be 729 nmol/min/mg using a synthetic peptide substrate (KKKVSRSGLYRSPSMPENLNRPR). |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Accession: NM_007194 |
|---|
| Catalog # | C4201-15B |
|---|
| Price | |
|---|
| Order / More Info | Chk2, active, Recombinant, Human (Checkpoint Kinase 2, Rad 53) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|