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| Product Name | CD56, aa1-711, Recombinant, Mouse (NCAM-1, Neural Cell Adhesion Molecule) |
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| Description | Purity ~95% (SDS-PAGE). Neural cell adhesion molecule 1 is a membrane-bound glycoprotein that plays an important role in nervous system development and function (1, 2). Mature mouse NCAM-1 consists of a 692aa extracellular domain (ECD) with five tandem Ig-like domains and two fibronectin type III domains, an 18aa transmembrane segment, and a 386aa cytoplasmic domain (3). Three major splice variants of NCAM-1 are expressed: the 180kD full length NCAM-180 isoform, the 140kD NCAM-140 isoform which lacks most of the cytoplasmic domain, and the 120kD GPI-anchored NCAM-120 isoform that includes the ECD only. Splicing is tissue specific and developmentally regulated (4-6). Within the ECD, mouse NCAM-1 shares 94% and 95% aa sequence identity with human and rat NCAM-1, respectively. It is expressed on neurons and glial cells, skeletal muscle, and immune NK cells (5, 7-9). NCAM-1 is extensively modified with polysialic acid (PSA) during development, but this addition is decreased in adult tissue |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_001106675 |
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| Catalog # | C2410-63M |
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| Order / More Info | CD56, aa1-711, Recombinant, Mouse (NCAM-1, Neural Cell Adhesion Molecule) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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