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| Product Name | Integrin alpha-v-beta3 Antagonist, P11 (HSDVHK, HSDVHK-NH2) |
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| Description | Purity ~95% (HPLC). A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Formula: C30H51N12O93· 3TFA Molecular Weight: 1062.9 Solubility: H2O (100mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217457 |
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| Order / More Info | Integrin alpha-v-beta3 Antagonist, P11 (HSDVHK, HSDVHK-NH2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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