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| Product Name | Integrin alphaV, beta3, Recombinant, Human |
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| Description | Purity ≥90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤0.1EU/ug (LAL). Integrin alphaVbeta3 together with aIIb-beta3, constitutes the only known beta3 Integrins). The non-covalent heterodimer of 170kD alphaV/CD51 and 93kD beta3/CD61 subunits show wide expression, notably by endothelial cells and osteoclasts. Each subunit has a transmembrane sequence and a short cytoplasmic tail connected to the cytoskeleton. Active cell surface alphaVbeta3 adheres to matrix proteins including vitronectin, fibronectin, fibrinogen and thrombospondin. The ligand binding site of alphaVbeta3 is in the N-terminal head region, formed by interaction of the beta3 vWFA domain with the alphaV beta-propeller structure. The alphaV subunit contributes a thigh and a calf region, while the beta3 subunit contains a PSI domain and four cysteine-rich I-EGF folds. The alphaV subunit domains termed thigh, calf-1 and calf-2 generate a ``knee'' region that is bent when the |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3685, Accession: NP_002201 (Integrin alpha V), AAA52589 (Integrin beta 3) |
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| Catalog # | I7661-37E9 |
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| Order / More Info | Integrin alphaV, beta3, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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