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| Product Name | Integrin alphaV, beta8, Recombinant, Human |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE and visualized by silver stain. Integrin αvβ8 is one of five αv integrins and the only known β8 integrin. 1-3 The non-covalent heterodimer of 170 kD αv and ~90 kD β8 integrin type I transmembrane glycoprotein subunits is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. 3-7 Unlike other αv integrins, αvβ8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. 3, 8 It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-β complex. 7-12 High affinity binding of αvβ8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-β. This mechanism differs from that of αvβ6, the other αv integrin which can activate TGF-β f |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_002201.1, SwissProt: P26012 |
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| Catalog # | I7661-37X8 |
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| Order / More Info | Integrin alphaV, beta8, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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