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| Product Name | Integrin alphaV beta1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE) Endotoxin: ≤1EU/1ug (LAL). Integrin aVB1 is one of five aV and twelve B1 containing Integrin family adhesion receptor heterodimers. The non-covalent heterodimer of 170kD aV and 130kD B1/CD29 is present on cells that express both subunits, and dimer formation is dependent on the availability of the individual subunits. Since the aV and B1 subunits are widely expressed, the aVB1 heterodimer potentially forms in many cell types. The 962 aa human aV extracellular domain (ECD) shares 92-95% aa sequence identity with mouse, rat and bovine aV, while the 708 aa human B1 ECD shares 92-96% aa sequence identity with mouse, rat, bovine and feline B1. The αV ECD contains an N-terminal B-propeller structure, followed by domains termed thigh, calf-1 and calf-2. The B1 ECD contains a vWFA domain, which participates in binding. Each subunit then has a transmembrane sequence and a short cytoplasmic tail. The dimer is folded when it is least active. Divalent cations and intra |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P05556 |
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| Catalog # | I7661-36S |
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| Order / More Info | Integrin alphaV beta1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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