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| Product Name | IAP-Like Protein 2, Blocking Peptide (ILP 2, Inhibitor of Apoptosis Protein) |
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| Description | Purified 60-70%. Synthetic peptide (TGYEARLITFGT) corresponding to amino acids 2 to 13 of human ILP-2 (1). Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits speci?c proteases. A novel member in the IAP protein family was recently identi?ed and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IA |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I0400P |
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| Order / More Info | IAP-Like Protein 2, Blocking Peptide (ILP 2, Inhibitor of Apoptosis Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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