| 产品详情 |
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| Product Name | Cyclopamine-KAAD |
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| Description | Purity ~70% (HPLC). A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Formula: C44H63N3O4 Primary Target: Hh signaling in Shh-light2 assay Primary Target IC50: 20nM Secondary Target: in P2Ptch-/-cells (IC50 = 50nM) Solubility: DMSO, EtOH, or MeOH Molecular Weight: 698 |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldihydrocinnamoyl cyclopamine, Shh Signaling Antagonist II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217304 |
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| Price | |
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| Order / More Info | Cyclopamine-KAAD from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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