| 产品详情 |
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| Product Name | ARE Activator, BTZO-1 |
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| Description | Purity ~95% (HPLC). A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (=68.6nM and 157nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30uM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330nM) from apoptotic death upon serum deprivation or DOX (200nM) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. Formula: C13H8N2OS Molecular Weight: 240.3 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ARE Activator, BTZO-1 (Macrophage Migration Inhibitory Factor Antagonist II, 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, MIF Antagonist II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217189 |
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| Price | |
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| Order / More Info | ARE Activator, BTZO-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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