| 产品详情 |
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| Product Name | Leptomycin B |
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| Description | Purity ~99% by HPLC. Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities. Solubility: Soluble in ethanol or methanol. Poor water solubility. Ethanol is recommended. Unstable in DMSO. |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | L1671-38A |
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| Price | |
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| Order / More Info | Leptomycin B from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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