| 产品详情 |
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| Product Name | 3,3'-Diamino-4'-methoxyflavone, DD1 |
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| Description | Purity ~98% (HPLC). A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Primary Target IC50: 2u Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217125 |
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| Order / More Info | 3,3'-Diamino-4'-methoxyflavone, DD1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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