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| Product Name | Mmp2, Recombinant, Rat, aa110-662, His-Tag (72kD Type IV Collagenase) |
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| Description | Purity ~85% (SDS-PAGE). Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading Extracellular domain matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels. Source: Recombinant protein corresponding to aa110-662 from human Mmp2, fused to His-Tag at N-terminal, expressed in Y |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 72kD gelatinase Gelatinase A Matrix metalloproteinase-2, MMP-2 |
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| Gene, Accession, CAS # | SwissProt: P33436 |
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| Catalog # | 374238 |
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| Order / More Info | Mmp2, Recombinant, Rat, aa110-662, His-Tag (72kD Type IV Collagenase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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