| 产品详情 |
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| Product Name | ITK Inhibitor, BMS-509744 |
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| Description | Purity ~97% (HPLC). A cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC50 = 19nM; [ATP] = 1uM) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn, IR, Lck, Btk only at much higher concentrations (IC50 ≥1.1uM) and exhibiting little or no activity against 14 other kinases (IC50 ≥11uM). Inhibits ITK-dependent cellular signaling (IC50 <300nM against alphaCD3-stimulated PLC-gamma1 Tyr phosphorylation and Ca2+ mobilization in Jurkat cells) in vitro and alleviate OVA challenge-induced airway leukocytes infiltration (ED50 = 25mg/kg s.c.) in OVA-sensitized mice in vivo. Formula: C32H41N5O4S2 Solubility: DMSO Primary Target: ITK Primary Target IC50: 19nM for ITK Molar Mass: 623.8 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ITK Inhibitor, BMS-509744 (BMS509744, EMT Inhibitor, IL-2-Inducible T Cell Kinase Inhibitor, N-(5-(5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenylthio)thiazol-2-yl)-4-((3,3-dimethylbutan-2-ylamino)methyl)benzamide, N-(5-((3-((4-Acetylpiperazin-1-yl)carbonyl)-4-methyl-6-methoxyphenyl)thio)thiazol-2-yl)-4-(N-1,2-dimethylpropylaminomethyl)benzamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217470 |
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| Order / More Info | ITK Inhibitor, BMS-509744 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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