| 产品名称 |
ITK, Recombinant, Human, GST-Tag (EMT, LYK, PSCTK2, MGC126257, MGC126258) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | ITK, Recombinant, Human, GST-Tag (EMT, LYK, PSCTK2, MGC126257, MGC126258) |
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| Description | Purified (~70-90%). ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK requires prior activation of LCK, ZAP70 and PI3-kinase for efficient activation and shares major substrates with both LCK and ZAP70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization. Source: Recombinant protein corresponding to human ITK fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~108kD Specific Activity: 50nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_005546 |
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| Catalog # | 500188 |
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| Price | |
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| Order / More Info | ITK, Recombinant, Human, GST-Tag (EMT, LYK, PSCTK2, MGC126257, MGC126258) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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