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| Product Name | ITPA, aa1-194, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). ITPA, also known as Inosine triphosphate pyrophosphatase, is an enzyme that catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPA can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPA result in ITPA deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts. Source: Recombinant corresponding to aa10194 of human ITPA protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MMAASLVGKK IVFVTGNAKK LEEVVQILGD KFPCTLVAQK IDLPEYQGEP DEISIQKCQE AVRQVQGPVL VEDTCLCFNA LGGLPGPYIK WFLEKLKPEG LHQLLAGFED KSAYALCTFA LSTGDPSQPV RLFRGRTSGR IVAPRGCQDF GWDPCFQPDG YEQTYAEMPK AEKNAVSHRF RALLELQEYF GSLAA Molecular Weigh |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ITPA, aa1-194, Recombinant, Human (Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphatase, Putative Oncogene Protein hlc14-06-p, C20orf37, My049, OK/SW-cl.9) |
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| Gene, Accession, CAS # | Accession: NP_258412 |
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| Catalog # | I9211-10 |
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| Order / More Info | ITPA, aa1-194, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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