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| Product Name | TLR1 Fc Chimera, Recombinant, Human |
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| Description | Purity ≥ 90% by SDSPAGE under reducing conditions and visualized by silver stain. The Tolllike family of molecules are type I transmembrane proteins that serve as pattern recognition receptors for microbial pathogens. There are at least eleven mouse and ten human TLRs that activate the innate immune system following exposure to a variety of microbial species (1, 2). TLRs contain a large number of leucinerich repeats (LRRs) and a cytoplasmic tail with one Tol l /IL1 receptor (TIR) domain. Mature human TLR1 consists of a 556 amino acid (aa) extracellular domain (ECD) with 20 LRRs, a 21 aa transmembrane segment, and a 185 aa cytoplasmic domain (3, 4). Within the ECD, human TLR1 shares 63% aa sequence identity with human TLR6 and 20% 43% aa sequence identitity with human TLR2, 3 , 4 , 5 , 7 , 8 , 9, and 10. It shares 73% and 71% aa sequence identity with mouse and rat TLR1, respectively. TLR1 is expressed on the surface of macrophages, dendritic cells, and tonsillar epithelial |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TLR1 Fc Chimera, Recombinant, Human (Toll-like receptor 1, CD281, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, rsc786, TIL, Toll/interleukin-1 receptor-like protein) |
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| Gene, Accession, CAS # | Accession: AAC34137 |
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| Catalog # | T8050-04B |
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| Order / More Info | TLR1 Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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