| 产品详情 |
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| Product Name | TLR3/dsRNA Complex Inhibitor |
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| Description | Purity ~99% (HPLC). A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Formula: C18H13ClFNO3S Molecular Weight: 377.8 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TLR3/dsRNA Complex Inhibitor (Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217837 |
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| Order / More Info | TLR3/dsRNA Complex Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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