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| Product Name | TLR11, Fc Chimera, Recombinant, Mouse (Toll-like Receptor 11, Gm287) |
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| Description | Purity ~95% (SDSPAGE). TLR11 is a type I transmembrane receptor of the Tolllike receptor family that is primarily expressed in epithelial cells in the liver, kidney, bladder and intestines, as well as in dendritic cells and macrophages (13). The 926 amino acid (aa) mouse TLR11 transcript encodes a 30 aa signal sequence, a 691 aa extracellular domain (ECD) with 10 leucinerich repeats and 9 potential Nglycosylation sites, a 21aa transmembrane domain, and a 184aa cytoplasmic domain with a TIR domain (1). Within the ECD, mouse and rat TLR11 share 86% aa sequence identity. Human TLR11 is a pseudogene that is not expressed. Some researchers have found TLR11 in the dendritic cell plasma membrane, where it cooperates with MyD88 to take up antigen and initiate cell signaling (35). Others have found it in the endoplasmic reticulum (ER), where it interacts with the multispan ER protein UNC93B1 (6). TLR11 recognizes profilin proteins on Toxoplasma gondii and other intracellular parasites (3, |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145845 |
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| Order / More Info | TLR11, Fc Chimera, Recombinant, Mouse (Toll-like Receptor 11, Gm287) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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