| 产品详情 |
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| Product Name | Ubiquitin+1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration. Source: Recombinant corresponding to aa1-96, with N-GST tag, from human Ubuiquitin +1, expressed in E.coli. Molecular Weight: ~37kD |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P62988 |
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| Catalog # | U1000-04R |
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| Order / More Info | Ubiquitin+1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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