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| Product Name | Cyp1b1, Recombinant, Rat, aa1-543, His-Tag (Cytochrome P450 1B1) |
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| Description | Purity ~90% (SDS-PAGE). Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CYPIB1 Cytochrome P450RAP |
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| Gene, Accession, CAS # | SwissProt: Q64678 |
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| Catalog # | 372954 |
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| Order / More Info | Cyp1b1, Recombinant, Rat, aa1-543, His-Tag (Cytochrome P450 1B1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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