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| Product Name | SB 203580 |
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| Description | Selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Essential component of medium for maintaining stem cells in naive pluripotent state. Available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Water-soluble Salt also available.. Purity 98%. MW (observed): 377.44 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
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| Gene, Accession, CAS # | CAS: 152121-47-6 |
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| Catalog # | 1202/1 |
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| Order / More Info | SB 203580 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 15152046, 15640157, 15659527, 16341839, 16397234, 16627622, 16672661, 17018141, 17145782, 17283097, 17714751, 18053155, 18258605, 18768402, 18815127, 18830681, 19371341, 19523197, 19723763, 19828633, 19887380, 20429916, 20631885, 20852130, 21440539, 21622856, 21642622, 21685895, 21738764, 21854542, 21904110, 21994479, 21995440, 22031657, 22057273, 22220695, 22275752, 22313861, 22328515, 22347375, 22432027, 22451267, 22848503, 23123784, 23315073, 23332156, 23536313, 23693126, 23748100, 23754277, 23967228, 24145351, 24152992, 24172903, 24222778, 24227191, 24280371, 24358263, 24531379, 24558305, 24627558, 24684682, 24736410, 25052197, 25214013, 25243776, 25260613, 25274725, 25398056, 25435694, 25582338, 25712213, 25878490, 25905635, 25936372, 25948586, 25999956, 26065826, 26116509, 26247711, 26251761, 26330750, 27150562, 27520483, 27802323, 28322749, 28442401, 30359318, 30797029 |
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