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| Product Name | SB 216763 |
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| Description | Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 34.3 nM for GSK-3α). Equally effective at inhibiting human GSK-3α and GSK-3β. Exhibits minimal activity against 24 other protein kinases (IC50 >10 μM). Stimulates glycogen synthesis in liver cells, and induces β-catenin-dependent gene transcription. Neuroprotective; also reduces pulmonary inflammation and fibrosis in a mouse model. Shown to maintain mouse embryonic stem cells in a pluripotent state. Purity 98%. MW (observed): 371.22 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
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| Gene, Accession, CAS # | CAS: 280744-09-4 |
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| Catalog # | 1616/1 |
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| Price | |
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| Order / More Info | SB 216763 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 14976126, 15044694, 16186256, 16341839, 16503970, 16504004, 16517948, 16551655, 16954147, 17018141, 17188038, 17192474, 17379415, 17400762, 17488622, 17517645, 17666435, 17921520, 17989287, 18223186, 18626679, 18677583, 18701682, 18952601, 18981097, 19020668, 19038340, 19050253, 19109187, 19407223, 19638411, 19734233, 19755104, 19778506, 19823589, 20117291, 20667980, 20679341, 20932480, 21092141, 21160051, 21398658, 21421749, 21422248, 21640723, 21738215, 21795403, 21931595, 21935433, 22340501, 22354041, 22649795, 22847803, 23468959, 23660596, 23789095, 24565756, 24610780, 24720754, 24722055, 24779365, 24974728, 25355946, 25561726, 25627813, 25918399, 26108621, 26348909, 26413502, 26528352, 26667040, 27870947 |
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