| 产品详情 |
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| Product Name | SB 218078 |
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| Description | Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. Purity 98%. MW (observed): 393.39 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
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| Gene, Accession, CAS # | CAS: 135897-06-2 |
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| Catalog # | 2560/1 |
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| Price | |
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| Order / More Info | SB 218078 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 19519883, 20844084, 21680529, 22876275, 24247150, 25761368 |
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| 产品资料 |
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