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| Product Name | HGF, Recombinant, Human, aa32-728 (Hepatopoietin A, Scatter Factor, SF) |
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| Description | Purity ~95% (SDS-PAGE). HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE-like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity (1-5). Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60kD alpha and 30kD beta chain. Alternate splicing generates human HGF isoforms that lack the proteinase-like domain and different numbers of the Kringle domains. Human Pro-HGF shares 90%-93% aa sequence identity with bovine, canine, feline, mouse, and rat Pro-HGF. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET (6, 7). HGF-dependent c-MET activation is implicated in the development of many human cancers (8). |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P14210 |
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| Catalog # | 145704 |
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| Order / More Info | HGF, Recombinant, Human, aa32-728 (Hepatopoietin A, Scatter Factor, SF) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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