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| Product Name | ICAD, Recombinant Human |
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| Description | Purity ~90% (SDS-PAGE). Purified by using conventional chromatography techniques. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA, also known as DNA fragmentation factor subunit alpha, is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Recombinant DFFA protein , expressed in E. coli and purified by using conventional chromatography techniques. Recombinant protein corresponding to human DFFA, aa1-331, His-tagged, expressed in E. coli Molecular Weight: ~38.7kD AA Sequence: MGSSHHHHHH SSGLVPRGSH MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LR |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ICAD, Recombinant Human (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase) |
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| Gene, Accession, CAS # | Accession: AAH07721 |
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| Catalog # | I0505-05T |
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| Order / More Info | ICAD, Recombinant Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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