| 产品详情 |
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| Product Name | AKR1C3 Inhibitor (3-(4-(Trifluoromethyl)phenylamino)benzoic Acid) |
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| Description | Purity ~99% (HPLC). A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17b-hydroxysteroid dehydrogenase) (IC50 = 60nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50uM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100uM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10uM). Formula: C14H10F3NO2 Molecular Weight: 281.2 Solubility: DMSO (50mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217168 |
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| Order / More Info | AKR1C3 Inhibitor (3-(4-(Trifluoromethyl)phenylamino)benzoic Acid) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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