| 产品详情 |
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| Product Name | Cuspin-1 |
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| Description | Purity ~94% (HPLC). A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48h; 5ug/ml), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24h; 10ug/ml), indicative of Ras-Raf-MEK signaling pathway activation. Solubility: DMSO Primary Target: Ras |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cuspin-1 ((5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron Protein Upregulator, Cuspin-1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217293 |
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| Price | |
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| Order / More Info | Cuspin-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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