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| Product Name | TBK1, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases. Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon. Source: Recombinant protein corresponding to human TBK1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~105kD Specific Activity: 282nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TBK1, Recombinant, Human, GST-Tag (TANK-Binding Kinase 1, NFkB-Activating Kinase, NAK, T2K, Serine/Threonine-Protein Kinase TBK1) |
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| Gene, Accession, CAS # | Accession: NM_013254, SwissProt: Q9UHD2 |
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| Catalog # | 500481 |
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| Order / More Info | TBK1, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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