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| Product Name | TMPRSS2, Recombinant, Human, aa106-492, His-Tag (Transmembrane Protease Serine 2) |
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| Description | Purity ~90% (SDS-PAGE). Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); invol |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Serine protease 10 |
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| Gene, Accession, CAS # | SwissProt: O15393 |
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| Catalog # | 375607 |
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| Order / More Info | TMPRSS2, Recombinant, Human, aa106-492, His-Tag (Transmembrane Protease Serine 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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