| 产品详情 |
| Edit |   |
|---|
| Product Name | DR6, Extracellular Domain, Recombinant, Human, aa42-349, His-Tag |
|---|
| Description | Purity ~95%. Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines. Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning. Source: Recombinant protein corresponding to human DR6 Extracellular Domain, fused to His-tag at C-terminal expressed |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | DR6, Extracellular Domain, Recombinant, Human, aa42-349, His-Tag (Death Receptor 6, BM018, MGC31965, TNFR Related Death Receptor 6, Tumor Necrosis Factor Receptor Superfamily Member 21, Tumor Necrosis Factor Receptor Superfamily Member 21 Precursor, TNFRSF21) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 149783 |
|---|
| Price | |
|---|
| Order / More Info | DR6, Extracellular Domain, Recombinant, Human, aa42-349, His-Tag from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|