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| Product Name | DR4, Fc Chimera, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Human TRAIL R1 also called DR4 (death receptor 4), is a 50-57kD, 468aa type 1 transmembrane protein in the TNF R family, designated TNFRSF10A. Of the five receptors for TRAIL (also called APO2 ligand) in humans, TRAIL R1/DR4 and TRAIL R2/DR5 are apoptosis-inducing and share 59% aa identity within the cytoplasmic death domain aa365- 448 of human TRAIL R1. Rodents do not express TRAIL R1/DR4. Human decoy receptors TRAIL R3 and TRAIL R4 have non-functional death domains but share ~60% aa identity with TRAIL R1 within extracellular TNFR domains aa107-229 while the secreted TRAIL receptor osteoprotegerin shares only 18% aa identity with TRAIL R1. Trimeric TRAIL engagement of TRAIL R1 induces apoptosis by recruiting a cytosolic death-inducing signaling complex (DISC) that includes the adaptor FADD and caspases 8 and 10. TRAIL R1 translational modifications, such as O-glycosylation and palmitoylation, promote apoptosis by enhancing oligomerization and presence in lipid |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DR4, Fc Chimera, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 10A, Death Receptor 4, TNF-related Apoptosis-inducing Ligand Receptor 1, TRAIL Receptor 1, TRAIL-R1, CD261, TNFRSF10A, APO2, TRAILR1) |
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| Gene, Accession, CAS # | Accession: AAC51226 |
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| Catalog # | D9300-36A |
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| Order / More Info | DR4, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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