| 产品详情 |
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| Product Name | TRPC3 Channel Inhibitor III, Pyr10 |
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| Description | Purity ~98% (HPLC). A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol-induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72uM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08uM; by Fura-2). A great complement to Pyr2, Pyr 3, and Pyr6 in Ca2+ signaling studies. Primary Target: TRPC3 Primary Target IC50: 720nM Molar Mass: 449.4 Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TRPC3 Channel Inhibitor III, Pyr10 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217850 |
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| Order / More Info | TRPC3 Channel Inhibitor III, Pyr10 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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