| 产品详情 |
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| Product Name | IRE1 Inhibitor I, STF-083010 |
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| Description | Purity ~98% (HPLC). A cell-permeable salicylidene compound that is shown to directly target Irea1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60uM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties. Formula: C15H11NO3S2 Molecular Weight: 317.4 Solubility: DMSO (100mg/ml clear, yellow solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IRE1 Inhibitor I, STF-083010 (N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217465 |
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| Order / More Info | IRE1 Inhibitor I, STF-083010 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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