| 产品详情 |
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| Antigenic Specificity | Human CD272 (BTLA) |
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| Clone | MIH26 |
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| Host Species | Mouse |
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| Reactive Species | human, African green |
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| Isotype | IgG2a, κ |
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| Format | TotalSeq™-C oligomer conjugate |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | PG |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TotalSeq™-C0170 anti-human CD272 (BTLA). B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It has been reported that BTLA may regulate T cell function through binding to B7-H4. |
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| Immunogen | Human BTLA transfected cells |
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| Other Names | BTLA, B and T lymphocyte attenuator |
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| Gene, Accession # | Gene ID: 151888 |
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| Catalog # | 344527 |
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| Price | |
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| Order / More Info | Human CD272 (BTLA) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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