| 产品详情 |
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| Antigenic Specificity | CD283 (TLR3) |
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| Clone | 11F8 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APC anti-mouse CD283 (TLR3). Toll-like receptor 3 (TLR3), also known as CD283, is type I transmembrane protein that belongs to the TLR family. It forms a large horseshoe shape that contacts a neighboring horseshoe, forming a dimer of two horseshoes. It is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. TLR3 is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. It is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens by recognizing polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. Ligand binding by TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. |
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| Immunogen | Recombinant mouse TLR3 extracellular domain. |
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| Other Names | Toll like receptor 3, TLR-3, CD283 |
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| Gene, Accession # | Gene ID: 142980 |
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| Catalog # | 141906 |
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| Price | |
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| Order / More Info | CD283 (TLR3) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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