产品详情 |
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Antigenic Specificity | CD283 (TLR3) |
Clone | 11F8 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a |
Format | phycoerythrin (PE) conjugate |
Size | 100 µg |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PE anti-mouse CD283 (TLR3). Toll-like receptor 3 (TLR3), also known as CD283, is type I transmembrane protein that belongs to the TLR family. It forms a large horseshoe shape that contacts a neighboring horseshoe, forming a dimer of two horseshoes. It is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. TLR3 is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. It is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens by recognizing polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. Ligand binding by TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. |
Immunogen | Recombinant mouse TLR3 extracellular domain. |
Other Names | Toll like receptor 3, TLR-3, CD283 |
Gene, Accession # | Gene ID: 142980 |
Catalog # | 141904 |
Price | |
Order / More Info | CD283 (TLR3) Antibody from BIOLEGEND |
Product Specific References | n/a |
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