| 产品详情 |
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| Antigenic Specificity | GARP |
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| Clone | 7B11 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | biotin conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Biotin anti-human GARP (LRRC32). Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs. |
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| Immunogen | LRRC32-DNA vaccination |
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| Other Names | Leucine-rich repeat-containing protein 32, Garpin, Glycoprotein A repetitions predominant |
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| Gene, Accession # | Gene ID: 2615 |
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| Catalog # | 352512 |
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| Price | |
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| Order / More Info | GARP Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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